A four-pillar causal-root-causes synthesis: viral persistence, microbiome dysbiosis, endothelial coagulopathy, and immune dysregulation — and the therapeutic pathways that target them.
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Building on the v3.2 Mechanistic Atlas, this synthesis translates 5,000+ peer-reviewed papers into an actionable therapeutic strategy. The report consolidates the field around four causal roots — viral persistence, microbiome dysbiosis, endothelial coagulopathy, and immune dysregulation — and identifies the highest-leverage interventions against each pillar.
It frames the case for prioritizing SIM01 → X.Dysbiosis — the sole Pearl-defensible therapeutic claim from the atlas — for accelerated trials, alongside a structured queue of RCT-ready candidates across antivirals, microbiome restoration, anti-coagulant protocols, and immunomodulation.
The deliverable is designed for clinicians, trial designers, funders, and policymakers who need a single coherent map of where to invest the next dollar of Long COVID research. Read the full report on Fleet for the complete chart set, scorecards, and the prioritized trial timeline.
Viral persistence, microbiome dysbiosis, endothelial coagulopathy, and immune dysregulation — with the therapeutic pathways that target each pillar.
Heatmap of candidate therapeutics across the four roots — mechanism coverage, evidence tier, and trial-readiness.
A prioritized RCT queue mapped onto a 36-month execution window, anchored by SIM01 → X.Dysbiosis as the lead claim.
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Improving and Accelerating Long COVID Treatment
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